I have a fedora 16 install with x86_64 in a AMD Dell Dimension C521.
Some times after screen saver, the pointer on the screen disappears. The mouse is still working. The hot spot like the upper left corner activate, some tabs highlight when pass over, if I click I got response. The problem is that I don't see the pointer on the screen, so clicking in the right point is a lot of guessing.
I have use Fedora 16 in my laptop and in a clone at home, and none of those show that weird behaviour.
Using lsusb the mouse is show as:
Bus 002 Device 003: ID 15ca:00c3 Textech International Ltd. Mini Optical Mouse
The mouse is labelled as Sam-Tech
I haven't linked to anything yet, so far it appear as random. And it is about one third of the time that the computer goes on the screen saver. What I do is to use Alt+F2 and then write reboot ... but it is getting annoying.