I have found that best font experience for me is hinting ‘none’/antialiasing LCD in gnome-tweak-tools. That makes Gnome fonts (e.g. Nautilus) look very good. Firefox is another beast. What made me happy was setting Xft resources setting also to same values as in Gnome. I also set DPI of my monitor in Xresources. I also switched Firefox display backend to Cairo Unfortuntely sites like Facebook seems to ignore Linux so I had to disable allowing sites to change font (probably it could be set in FreeType config to subsitute Facebook font also)
How are yours experience with Linux desktop ?